Photo of Weihua Guan

Weihua Guan

Assistant Professor

Affiliation(s):

  • School of Electrical Engineering and Computer Science
  • Electrical Engineering
  • Biomedical Engineering

111F Electrical Engineering West

wzg111@psu.edu

814-867-5748

Personal or Departmental Website

Research Areas:

Biomedical Devices and Systems; Electronic Materials and Devices; Optical Materials, Devices, and Systems

Interest Areas:

Electro-fluidic and opto-fluidic devices and systems for biosensing and actuation, bioMEMS/NEMS, Lab-on-a-chip, Micro/Nanofluidics, Electrokinetic Phenomena, Point-of-care Testing.

 
 

 

Education

  • BS, Electrical Engineering, Nanjing University of Science and Technology, 2005
  • MS, Microelectronics and Solid State Electronics, Chinese Academy of Science, 2008
  • Ph D, Electrical Engineering, Yale University, 2013

Publications

Book, Chapters

  • Weihua Guan and Mark Reed, 2017, Extended gate field-effect transistor biosensors for point-of-care testing of uric acid, Humana Press, New York, NY

Journal Articles

  • Reza Nouri, Zifan Tang and Weihua Guan, 2019, "Calibration-Free Nanopore Digital Counting of Single Molecules", Analytical Chemistry, 91, (17), pp. 10915-11488
  • Wenchang Zhang, Yuan Hu, Gihoon Choi, Shengfa Liang, Ming Liu and Weihua Guan, 2019, "Microfluidic multiple cross-correlated Coulter counter for improved particle size analysis", Sensors and Actuators B: Chemical, 296, pp. 126615
  • Gihoon Choi, Erica Murphy and Weihua Guan, 2019, "Microfluidic Time-Division Multiplexing Accessing Resistive Pulse Sensor for Particle Analysis", ACS Sensors, 4, (7), pp. 1957-1963
  • Kamyar Akbari Roshan, Zifan Tang and Weihua Guan, 2019, "High fidelity moving Z-score based controlled breakdown fabrication of solid-state nanopore", Nanotechnology, 30, pp. 095502
  • Gihoon Choi, Theodore Prince, Jun Miao, Liwang Cui and Weihua Guan, 2018, "Sample-to-answer palm-sized nucleic acid testing device towards low-cost malaria mass screening", Biosensors and Bioelectronics, 115, pp. 83-90
  • Taehwan Kim, Jared S. Price, Alex Grede, Sora Lee, Gihoon Choi, Weihua Guan, Thomas N Jackson and Noel Giebink, 2018, "Kirigami-Inspired 3D Organic Light-Emitting Diode (OLED) Lighting Concepts", Advanced Materials Technologies, 3, (7), pp. 1800067
  • Xiaonan Yang, Zhuofa Chen, Jun Miao, Liwang Cui and Weihua Guan, 2017, "High-throughput and label-free parasitemia quantification and stage differentiation for malaria-infected red blood cells", Biosensors and Bioelectronics, 98, pp. 408-414
  • Gihoon Choi, Daniel Song, Sony Shrestha, Jun Miao, Liwang Cui and Weihua Guan, 2016, "A field-deployable mobile molecular diagnostic system for malaria at the point of need", Lab on a Chip, 16, (22), pp. 4341–4349
  • Zhuofa Chen, Weizhi Li, Gihoon Choi, Xiaonan Yang, Jun Miao, Liwang Cui and Weihua Guan, 2016, "Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening", Sensors, 16, (10), pp. 1616
  • Sylvia Xin Li, Weihua Guan, Benjamin Weiner and Mark A Reed, 2015, "Direct observation of charge inversion in divalent nanofluidic devices", Nano Letters, 15, (8), pp. 5046–5051
  • Weihua Guan, Liben Chen, Tushar D Rane and Tza-Huei Wang, 2015, "Droplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification", Scientific Reports, 5, pp. 13795
  • Weihua Guan, Xuexin Duan and Mark A Reed, 2014, "Highly specific and sensitive non-enzymatic determination of uric acid in serum and urine by extended gate field effect transistor sensors", Biosensors and Bioelectronics, 51, pp. 225–231
  • Weihua Guan, Sylvia Xin Li and Mark A Reed, 2014, "Voltage gated ion and molecule transport in engineered nanochannels: theory, fabrication and applications", Nanotechnology, 25, (12), pp. 122001
  • Weihua Guan, Nitin K Rajan, Xuexin Duan and Mark A Reed, 2013, "Quantitative probing of surface charges at dielectric–electrolyte interfaces", Lab on a Chip, 13, (7), pp. 1431–1436
  • Weihua Guan and Mark A Reed, 2012, "Electric field modulation of the membrane potential in solid-state ion channels", Nano Letters, 12, (12), pp. 6441–6447
  • Jae Hyun Park, Weihua Guan, Mark A Reed and Predrag S Krstic, 2012, "Tunable aqueous virtual micropore", Small, 8, (6), pp. 907–912
  • Weihua Guan, Rong Fan and Mark A Reed, 2011, "Field-effect reconfigurable nanofluidic ionic diodes", Nature Communications, 2, pp. 506
  • Weihua Guan, Jae Hyun Park, Predrag S Krstic and Mark A Reed, 2011, "Non-vanishing ponderomotive AC electrophoretic effect for particle trapping", Nanotechnology, 22, (24), pp. 245103
  • Weihua Guan, Sony Joseph, Jae Hyun Park, Predrag S Krstic and Mark A Reed, 2011, "Paul trapping of charged particles in aqueous solution", Proceedings of the National Academy of Sciences, 108, (23), pp. 9326–9330
  • Sony Joseph, Weihua Guan, Mark A Reed and Predrag S Krstic, 2010, "A long DNA segment in a linear nanoscale Paul trap", Nanotechnology, 21, (1), pp. 015103
  • Ming Liu, Z Abid, Wei Wang, Xiaoli He, Qi Liu and Weihua Guan, 2009, "Multilevel resistive switching with ionic and metallic filaments", Applied Physics Letters, 94, (23), pp. 233106
  • Weihua Guan, Shibing Long, Yuan Hu, Qi Liu, Qin Wang and Ming Liu, 2009, "Resistance switching characteristics of zirconium oxide containing gold nanocrystals for nonvolatile memory applications", Journal of nanoscience and nanotechnology, 9, (2), pp. 723–726
  • Sen Zhang, Shibing Long, Weihua Guan, Qi Liu, Qin Wang and Ming Liu, 2009, "Resistive switching characteristics of MnOx-based ReRAM", Journal of Physics D: Applied Physics, 42, (5), pp. 055112
  • Qi Liu, Shibing Long, Weihua Guan, Sen Zhang, Ming Liu and Chen Junning, 2009, "Unipolar resistive switching of Au+-implanted ZrO2 films", Journal of Semiconductors, 30, (4), pp. 042001
  • Zhigang Li, Weihua Guan, Ming Liu, Shibing Long, Rui Jia, Jin Lv, Yi Shi and Xinwei Zhao, 2008, "Charge storage characteristics of metal-induced nanocrystalline in erbium-doped amorphous silicon films", Thin Solid Films, 516, (21), pp. 7657–7660
  • Qin Wang, Rui Jia, Weihua Guan, Weilong Li, Qi Liu, Yuan Hu, Shibing Long, Baoqin Chen, Ming Liu, Tianchun Ye and others, 2008, "Comparison of discrete-storage nonvolatile memories: advantage of hybrid method for fabrication of Au nanocrystal nonvolatile memory", Journal of Physics D: Applied Physics, 41, (3), pp. 035109
  • Weihua Guan, Shibing Long, Qi Liu, Ming Liu and Wei Wang, 2008, "Nonpolar Nonvolatile Resistive Switching in Cu Doped", Electron Device Letters, IEEE, 29, (5), pp. 434–437
  • Weihua Guan, Ming Liu, Shibing Long, Qi Liu and Wei Wang, 2008, "On the resistive switching mechanisms of Cu/ZrO2: Cu/Pt", Applied Physics Letters, 93, (22), pp. 223506
  • Lijuan Zhen, Weihua Guan, Liwei Shang, Ming Liu and Ge Liu, 2008, "Organic thin-film transistor memory with gold nanocrystals embedded in polyimide gate dielectric", Journal of Physics D: Applied Physics, 41, (13), pp. 135111
  • Qi Liu, Weihua Guan, Shibing Long, Ming Liu, Sen Zhang, Qin Wang and Junning Chen, 2008, "Resistance switching of Au-implanted-ZrO2 film for nonvolatile memory application", Journal of Applied Physics, 104, (11), pp. 114514
  • Qi Liu, Weihua Guan, Shibing Long, Rui Jia, Ming Liu and Junning Chen, 2008, "Resistive switching memory effect of ZrO2 films with Zr+ implanted", Applied Physics Letters, 92, (1), pp. 12117–12117
  • Weihua Guan, Shibing Long, Ming Liu, Zhigang Li, Yuan Hu and Qi Liu, 2007, "Fabrication and charging characteristics of MOS capacitor structure with metal nanocrystals embedded in gate oxide", Journal of Physics D: Applied Physics, 40, (9), pp. 2754
  • Weihua Guan, Shibing Long, Ming Liu, Qi Liu, Yuan Hu, Zhigang Li and Rui Jia, 2007, "Modeling of retention characteristics for metal and semiconductor nanocrystal memories", Solid-State Electronics, 51, (5), pp. 806–811
  • Weihua Guan, Shibing Long, Rui Jia and Ming Liu, 2007, "Nonvolatile resistive switching memory utilizing gold nanocrystals embedded in zirconium oxide", Applied Physics Letters, 91, (6), pp. 62111–62111

Conference Proceedings

  • Kamyar Roshan and Weihua Guan, 2019, "False negative and false positive free nanopore fabrication via adaptive learning of the controlled dielectric breakdown", Transducers
  • Gihoon Choi and Weihua Guan, 2019, "Non-centrifugal microfluidic nucleic acid testing on lab-on-a-disc", Transducers
  • Kamyar Akbari Roshan and Weihua Guan, 2019, "Optically Assisted Localization of Solid-State Nanopore during Controlled Breakdown Fabrication", Biophysical Society Annual Meeting, 116, (3), pp. 293A-293A
  • Zifan Tang and Weihua Guan, 2019, "Real-Time Nanopore Couting of Amplicons for Ultrasensitive and Lable-Free Sequence-Specific DNA Detection", Biophysical Society Annual Meeting, 116, (3), pp. 149A-149A
  • Reza Nouri, Zifan Tang and Weihua Guan, 2019, "Calibration-Free Nanopore Digital Counting of Single Molecules", BMES Annual Meeting
  • Gihoon Choi, Reza No andri, , 2019, "Microfluidic Deformability-activated Cell Sorting (DACS)", BMES Annual Meeting
  • Gihoon Choi and Weihua Guan, 2019, "Live Demonstration: Sample-to-Answer Nucleic Acid Testing Device for Point-of-Care Applications", IEEE Sensor
  • Gihoon Choi, Erica Murphy and Weihua Guan, 2019, "Time-division multiplexed resistive pulse sensor on a microfluidic chip", IEEE Sensor
  • Reza Nouri, Zifan Tang and Weihua Guan, 2019, "Calibration-Free Electrical Quantification of Single Molecules Using Nanopore Digital Counting", IEEE Sensor
  • Gihoon Choi, Theodore Prince, Jun Miao, Liwang Cui and Weihua Guan, 2017, "Portable sample-to-answer multiplexed molecular diagnosis for malaria in remote areas", MicroTAS
  • Gihoon Choi, Theodore Prince, Jun Miao, Liwang Cui and Weihua Guan, 2017, "Point Of Care Nucleic Acid Testing For Highly Sensitive Genus- And Species- Specific Detection of Malaria", HI-POCT
  • Gihoon Choi, Daniel Song, Jun Miao, Liwang Cui and Weihua Guan, 2017, "Sample-to-answer mobile malaria molecular diagnostic system for resource-limiting areas", IEEE MEMS
  • Xiaonan Yang, Zhuofa Chen, Gihoon Choi, Jun Miao, Liwang Cui and Weihua Guan, 2017, "High-throughput and label-free parasitemia quantification and stage determination for plasmodium falciparum-infected red blood cells", IEEE MEMS
  • Gihoon Choi, Daniel Song, Jun Miao, Liwang Cui and Weihua Guan, 2016, "Mobile all-in-one malaria molecular diagnosis for field deployment in resource-limited areas", HI-POCT
  • Weihua Guan, 2016, "Drop-n-Go Malaria Molecular Diagnosis", Biodefense World Summit
  • Weihua Guan, 2016, "Microfluidic Combinatory Chip for High-Throughput Drug Screening", Biodefense World Summit
  • Weihua Guan, Liben Chen, Tushar Rane, Aniruddha Kaushik and Jeff Tza-Huei Wang, 2015, "Digital droplet ELOHA for nucleic acid molecule counting and analysis", Transducers, pp. 460–463
  • Weihua Guan, Rong Fan and Mark A Reed, 2013, "Field Effect Ionics In Nanochannels", Connecticut Microelectronics and Optoelectronics Symposium
  • Weihua Guan, Rong Fan and Mark A Reed, 2012, "Solid-state Nanofluidic Ion Channels", Gordon Research Conference-Nanostructure Fabrication
  • Weihua Guan, Rong Fan and Mark A Reed, 2012, "Fabrication and Characterization of Field Effect Reconfigurable Nanofluidic Ionic Diodes: Building Blocks Towards Digitally-Programmed Manipulation of Biomolecules", International Conference on Electron, Ion, and Photon Beam Technology and Nanofabrication
  • Weihua Guan, Rong Fan and Mark A Reed, 2012, "Fabrication and characterization of field effect reconfigurable nanofluidic ionic diodes: Towards digitally-programmed manipulation of biomolecules", Device Research Conference
  • Predrag Krstic, Mark Reed, Weihua Guan and J.H. Park, 2011, "DNA Transport and Sequencing Through a Quadrupole Gate", NHGRI DNA Sequencing Technology Development Grantee Meeting
  • Weihua Guan, JaeHyun Park, Predrag Krstic and Mark Reed, 2011, "AC electrophoretic effect in inhomogeneous electrical field: potentials for single molecule trapping", APS March Meeting
  • Weihua Guan, Mark Reed, Sony Joseph and Predrag Krstic, 2010, "Suppression of Brownian motion by electrodynamic confinement in aqueous solution", APS March Meeting
  • Predrag Krstic, Mark Reed, Weihua Guan and J.H. Park, 2010, "DNA Transport and Sequencing Through a Quadrupole Gate", NHGRI DNA Sequencing Technology Development Grantee Meeting
  • Ming Liu, Qi Liu, Shibing Long and Weihua Guan, 2010, "Formation and annihilation of Cu conductive filament in the nonpolar resistive switching Cu/ZrO 2: Cu/Pt ReRAM", IEEE International Symposium on Circuits and Systems
  • R Munden, A Vacic, E Castiglione, Weihua Guan, C Broadbridge and Mark Reed, 2009, "Aligned Gallium Nitride Nanowire Growth by Chemical Beam Epitaxy Method", APS March Meeting
  • Predrag Krstic, Mark Reed, Sony Joseph and Weihua Guan, 2009, "DNA Transport and Sequencing Through a Quadrupole Gate", NHGRI DNA Sequencing Technology Development Grantee Meeting
  • Weihua Guan, Ming Liu, Z Li, Y Hu, S Long and R Jia, 2008, "Simulation, Fabrication and Characteristics of Nanocrystal Non-Volatile Memories", IEEE International Nanoelectronics Conference
  • Ming Liu, Weihua Guan, Shibing Long, Qi Liu and Wei Wang, 2008, "Excellent resistive switching characteristics of Cu doped ZrO 2 and its 64 bit cross-point integration", IEEE International Conference on Solid-State and Integrated Circuit Technology, pp. 905–908
  • Weihua Guan, Shibing Long, Ming Liu and Wei Wang, 2008, "Nonvolatile resistive switching characteristics of HfO 2 with Cu doping", MRS Spring Meeting, Cambridge University Press, 1071, pp. 1071–F07
  • Q Wang, R Jia, WL Li, Weihua Guan, Q Liu, Y Hu, SB Long, BQ Chen, M Liu, TC Ye and others, 2007, "A hybrid method for fabrication of Au nanocrystals nonvolatile memory", IEEE Conference on Nanotechnology, pp. 938–941
  • Weihua Guan, Shibing Long, Rui Jia, Qi Liu, Yuan Hu, Qin Wang and Ming Liu, 2007, "Analysis of Charge Retention Characteristics for Metal and Semiconductor Nanocrystal Non-volatile Memories", IEEE International Conference on Electron Devices and Solid-State Circuits, pp. 141–144
  • W Guan, Z Li, Y Hu, SB Long and R Jia, 2007, "Nanocrystal Non-Volatile Memories: Simulation, Fabrication and Characteristics", International Conference on Micro- and Nano-Engineering, pp. 938–941

Research Projects

Honors and Awards

Service

Service to Penn State:

Service to External Organizations:

 


 

About

The School of Electrical Engineering and Computer Science was created in the spring of 2015 to allow greater access to courses offered by both departments for undergraduate and graduate students in exciting collaborative research in fields.

We offer B.S. degrees in electrical engineering, computer science, computer engineering and data science and graduate degrees (master's degrees and Ph.D.'s) in electrical engineering and computer science and engineering. EECS focuses on the convergence of technologies and disciplines to meet today’s industrial demands.

School of Electrical Engineering and Computer Science

The Pennsylvania State University

207 Electrical Engineering West

University Park, PA 16802

814-863-6740

Department of Computer Science and Engineering

814-865-9505

Department of Electrical Engineering

814-865-7667