Photo of Siyang Zheng

Siyang Zheng

Associate Professor


  • Biomedical Engineering
  • School of Electrical Engineering and Computer Science
  • Electrical Engineering

N238 Millennium Science Complex


Personal or Departmental Website

Research Areas:

BioMEMS and Nanotechnology

Interest Areas:





Parts of Book

  • Siyang Zheng, K. Shaikh and J. Xie, 2010, Fluid Control Pumps and Valves. Microflow Cytometer, Pan Stanford Publishing, Hackensack, NJ, USA
  • H. Lin, Siyang Zheng, M. Balic, R. J. Cote, Y.-C. Tai and R. H. Datar, 2009, Microfabricated Devices for Detection of Circulating Tumor Cells in Cancer Patient Blood Samples, Artech House, Norwood, MA, USA

Journal Articles

  • Yuan Wan, Gong Cheng, Xin Liu, Si-Jie Hao, Merisa Nisic, Chuan-Dong Zhu, Yi-Qiu Xia, Wen-Qing Li, Zhi-Gang Wang, Wen-Long Zhang, Shawn J Rice, Aswathy Sebastian, Istvan Albert, Chandra P Belani and Si-Yang Zheng, 2017, "Rapid isolation of extracellular vesicles via lipid nanoprobes", Nature Biomedical Engineering
  • Yiqiu Xia, Yi Tang, Xu Yu, Yuan Wan, Yizhu Chen, Huaguang Lu and Siyang Zheng, 2017, "Label-free virus capture and release by a microfluidic device integrated with porous silicon nanowire forest", Journal
  • Y. T. Yeh, R. A. Harouaka and Siyang Zheng, 2017, "Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA)", Journal, 17, (4), pp. 691-701
  • Gong Cheng, Si-Jie Hao, Yuan Wan, Ding-Ying Shan, Jian Yang and Si-Yang Zheng, 2017, "Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity", Journal
  • Xu Yu, Yiqiu Xia, Yi Tang, Wen-Long Zhang, Yin-Ting Yeh, Huaguang Lu and Si-Yang Zheng, 2017, "A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection", Small, 13, (24)
  • Ming-Da Zhou, Muhammad Akbar, Andrew J Myrick, Yiqiu Xia, Waleed J. Khan, Xiang Gao, Thomas C Baker and Si-Yang Zheng, 2017, "Chopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device", MICROSYSTEMS & NANOENGINEERING, 3
  • Wen-Qing Li, Zhigang Wang, Sijie Hao, Hongzhang He, Yuan Wan, Chuandong Zhu, Li-Ping Sun, Gong Cheng and Si-Yang Zheng, 2017, "Mitochondria-Targeting Polydopamine Nanoparticles To Deliver Doxorubicin for Overcoming Drug Resistance", ACS APPLIED MATERIALS & INTERFACES, 9, (20), pp. 16794-16803
  • Jinshan Guo, Wei Wang, Jianqing Hu, Denghui Xie, Ethan Gerhard, Merisa Nisic, Dingying Shan, Guoying Qian, Siyang Zheng and Jian Yang, 2016, "Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives", Biomaterials
  • Yin-Ting Yeh, Yi Tang, Aswathy Sebastian, Archi Dasgupta, Nestor Perea-Lopez, Istvan Albert, Huaguang Lu, Mauricio Terrones and Si-Yang Zheng, 2016, "Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays", Science Advances
  • Chenji Zhang, Gong Cheng, Perry Edwards, Ming-Da Zhou, Si-Yang Zheng and Zhiwen Liu, 2016, "G-Fresnel smartphone spectrometer", Lab on a Chip
  • E. M. Matthew, L. Zhou, Zifeng Yang, D. T. Dicker, S. L. Holder, B. Lim, R. Harouaka, Siyang Zheng, J. J. Drabick, N. E. Lamparella, C. I. Truica and W. S. El-Deiry, 2016, "A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells", 7, (4), pp. 3662-76
  • G. Cheng, Zhiren Wang, S. Denagamage and Siyang Zheng, 2016, "Graphene-Templated Synthesis of Magnetic Metal Organic Framework Nanocomposites for Selective Enrichment of Biomolecules", 8, (16), pp. 10234-42
  • Yanyuan Ma, S. Hao, Shuwen Wang, Y. Zhao, B. Lim, M. Lei, David J Spector, W. S. El-Deiry, Siyang Zheng and Jun Zhu, 2015, "A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus", Mol Cancer Ther, 14, (3), pp. 835-43
  • J. T. Kaifi, M. Kunkel, Arunangshu das, R. A. Harouaka, D. T. Dicker, G. Li, Jun Zhu, Gary A Clawson, Zifeng Yang, M. F. Reed, N. J. Gusani, E. T. Kimchi, K. F. Staveley-O’Carroll, Siyang Zheng and W. S. El-Deiry, 2015, "Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques", 16, (5), pp. 699-708
  • Y. Tang, Huaguang Lu, A. Sebastian, Y. T. Yeh, Craig A Praul, Istvan Albert and Siyang Zheng, 2015, "Genomic characterization of a turkey reovirus field strain by Next-Generation Sequencing", 32, pp. 313-21
  • X. Yu, Zhihua Zhang and Siyang Zheng, 2015, "Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization", 66, (0), pp. 520-6
  • G. Cheng, S. J. Hao, X. Yu and Siyang Zheng, 2015, "Nanostructured microfluidic digestion system for rapid high-performance proteolysis", 15, (3), pp. 650-4
  • X. Yu, G. Cheng, M. D. Zhou and Siyang Zheng, 2015, "On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics", 31, (13), pp. 3982-92
  • Ramdane Harouaka, Zhigang Kang, Si-Yang Zheng and Liang Cao, 2014, "Circulating tumor cells: Advances in isolation and analysis, and challenges for clinical applications", 141, (2), pp. 209-221
  • G. Cheng and Siyang Zheng, 2014, "Construction of a high-performance magnetic enzyme nanosystem for rapid tryptic digestion", 4, pp. 6947
  • R. A. Harouaka, M. D. Zhou, Y. T. Yeh, W. J. Khan, Arunangshu das, Xin Liu, C. C. Christ, D. T. Dicker, T. S. Baney, J. T. Kaifi, C. P. Belani, C. I. Truica, W. S. El-Deiry, J. P. Allerton and Siyang Zheng, 2014, "Flexible micro spring array device for high-throughput enrichment of viable circulating tumor cells", 60, (2), pp. 323-33
  • M. D. Zhou, S. Hao, A. J. Williams, R. A. Harouaka, B. Schrand, S. Rawal, Z. Ao, R. Brennaman, E. Gilboa, B. Lu, Shuwen Wang, Jun Zhu, R. Datar, R. Cote, Y. C. Tai and Siyang Zheng, 2014, "Separable Bilayer Microfiltration Device for Viable Label-free Enrichment of Circulating Tumour Cells", 4, pp. 7392
  • R. A. Harouaka, M. Nisic and Siyang Zheng, 2013, "Circulating tumor cell enrichment based on physical properties", 18, pp. 455-468
  • J.-N. Gallant, E. M. Matthew, H. Cheng, R. Harouaka*, N. E. Lamparella, M. Kunkel, Z. Yang, H. A. Harvey, L. V. Cream, S. M. Kumar, G. P. Robertson, Siyang Zheng, J. J. Drabick, C. I. Truica and W. S. El-Deiry, 2013, "Predicting therapy response in live tumor cells isolated with the flexible micro spring array device", 12, pp. 2132-2143
  • B. Ramaswamy*, Y. T. Yeh* and S.-Y. Zheng, 2013, "Microfluidic device and system for point-of-care blood coagulation measurement based on electrical impedance sensing", 180, pp. 21-27
  • Ramdane A. Harouaka, Merisa Nisic and Si-Yang Zheng, 2013, "Circulating Tumor Cell Enrichment Based on Physical Properties", Journal of Laboratory Automation, 18, (6), pp. 455 - 468
  • Bharath Ramaswamy, Yin-Ting Tim Yeh and Si-Yang Zheng, 2013, "Microfluidic device and system for point-of-care blood coagulation measurement based on electrical impedance sensing", Sensors and Actuators B: Chemical, 180, (0), pp. 21-27
  • Jean-Nicolas Gallant, Elizabeth M. Matthew, Hairong Cheng, Ramdane Harouaka, Nicholas E. Lamparella, Miriam Kunkel, Zhaohai Yang, Harold A. Harvey, Leah V. Cream, Suresh Kumar, Gavin P Robertson, Siyang Zheng, Joseph J. Drabick, Cristina I. Truica and Wafik S. El-Deiry, 2013, "Predicting therapy response in live tumor cells isolated with the flexible micro spring array device", Cell Cycle, 12, (13), pp. 2132-2143
  • M.-D. Zhou, C. Yang, Z. Liu, J. P. Cysyk and Siyang Zheng, 2012, "An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure", 14, pp. 235-245
  • Ming-Da Zhou, Chuan Yang, Zhiwen Liu, Joshua Peter Cysyk and Si-Yang Zheng, 2012, "An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure", Biomedical Microdevices, 14, (1), pp. 235-245
  • Gary A Clawson, Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Steven Berg, Todd Schell, Kevin F. Staveley-O’Carroll, Rogerio I. Neves, Paul J. Mosca and Diane Thiboutot, 2012, "Circulating Tumor Cells in Melanoma Patients", 7, (7), pp. e41052
  • Chuan Yang, Kebin Shi, Mingda Zhou, Siyang Zheng, Shizhuo Yin and Zhiwen Liu, 2012, "Z-microscopy for parallel axial imaging with micro mirror array", 101, (23), pp. 231111-5
  • Siyang Zheng, H. K. Lin, B. Lu, A. Williams, R. H. Datar, R. J. Cote and Y.-C. Tai, 2011, "3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood", 13, pp. 203-213
  • H. K. Lin, Siyang Zheng, A. J. Williams, M. Balic, S. Groshen, H. I. Scher, M. Fleisher, W. Stadler, R. H. Datar, Y.-C. Tai and R. J. Cote, 2011, "Portable filter-based microdevice for detection and characterization of circulating tumor cells", 16, pp. 5011-5018
  • Henry Lin, Marija Balic, Siyang Zheng, Ram Datar and Richard J. Cote, 2011, "Disseminated and circulating tumor cells: Role in effective cancer management", 77, (1), pp. 1-11
  • B. Lu, Siyang Zheng, B. Q. Quach and Y.-C. Tai, 2010, "The autofluorescence study of parylene materials for µTAS applications", 10, (14), pp. 1826-1834
  • Siyang Zheng, J. C.-H. Lin, H. L. Kasdan and Y. C. Tai, 2008, "Leukocyte Counting and Differentiation from Undiluted Whole Blood Samples", 132, pp. 558-576
  • Siyang Zheng, M. Liu and Y. C. Tai, 2008, "Micro coulter counters with platinum black electroplated electrodes for human blood cell sensing", 10, (2), pp. 221-31
  • Siyang Zheng, Mandheerej S. Nandra, Chi-Yuan Shih, Wei Li and Yu-Chong Tai, 2008, "Resonance impedance sensing of human blood cells", 145–146, (0), pp. 29-36
  • Siyang Zheng, Hangsheng Lin, Jude Liu, M. Balic, R. Datar, R. J. Cote and Y. C. Tai, 2007, "Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells", 1162, (2), pp. 154-61

Research Projects

Honors and Awards


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The School of Electrical Engineering and Computer Science was created in the spring of 2015 to allow greater access to courses offered by both departments for undergraduate and graduate students in exciting collaborative research in fields.

We offer B.S. degrees in electrical engineering, computer science, computer engineering and data science and graduate degrees (master's degrees and Ph.D.'s) in electrical engineering and computer science and engineering. EECS focuses on the convergence of technologies and disciplines to meet today’s industrial demands.

School of Electrical Engineering and Computer Science

The Pennsylvania State University

207 Electrical Engineering West

University Park, PA 16802


Department of Computer Science and Engineering


Department of Electrical Engineering